[Perfectlap]

^you want to strip off the protectant because those protectants are not brake-dust proof. Hot brake dust will melt right through those protectants easily and then adhere to the clear coat. You can't let ferrous particles linger over your clear coat and you certainly don't want to spread them around when you wax you wheels as you will be scratching the clear coat.
The dedicated wheel cleaner is the most potent so you do the job quickly. Some wheel cleaner have no acids so they are completely safe to your clear coat.
P21S is the best example of this, you can leave it on for hours and it won't hurt your wheels clear coat. The other wheels cleaners should be washed off right away.