That is similar to my rig which sounds pretty good but still needs a subwoofer. It is especially useful to have the multiband equalizer with found with the better pioneer head units. I then use a 1/3 octive real time analyzer and pink noise generator to try to dial in the equalizer settings to the car.
Pioneer Head unit
JL Audio Slash series 5-channel amp
2 X 6" JL audio speakers in the door
2 S 5" JL audio speakers in the dash (needed to mod for larger speakers)
4 X 3" JL audio speakers in the rear
Ed