I have found that the buttons on my FOB press against other items in my pocket and was causing a drain of the battery or if near my car has set off the alarm or unarmed it. I have started making sure that I take my keys out of my pocket while sitting for long periods (at work) and make sure I have nothing else in the same pocket.
I have kept the same battery for my Lexus for two years and it is a daily driver, with the Box my battery lasted about two months prior to me changing the way I kept the key in my pocket, since then I have had the same battery for about 8 months.
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