Good tires and brakes, a less-than-5-yr-old battery, reasonably fresh fluids. Drive it!
For reference:
We just completed a 15,000 mile, 30 state USA tour in a MB Sprinter based RV. MB is not well known for long term reliability but this rig was nearly flawless for 5 months. We did develop a slight exhaust leak on the home stretch but it looks like it will get covered under an emissions recall at no cost. I brought a lot of tools and spares just in case but they mostly were unnecessary.
Cheers!