There you go, Ohioboxster is living testement to what a little boost can do (albeit, not too much).
I believe that turbochargers/superchargers get a bad rap in the tuner world for reliability because people are constantly pushing the bounderies or not tuning them appropriately (or both).
The first thing they do with a supercharged vehicle is figure out where to get a pulley the size of a coke bottle cap and overclock the blower. Turbo owners purchase an aquarium bleeder valve or M.B.C. and basically run closed wastegate until they melt something. I did it once years back, its part of growing up.
If there are companies like Comptech offering supercharger kits for the S2000 (with and w/o intercoolers) that has 11.1:1 compression and a 9k redline I think anything can take a *little* boost.