I agree, it would take a lot of treatments to move that kind of buildup, and you'd still have staining to remove anyway. A wheel brush like a Daytona Speedbrush is the best weapon in your arsenal against buildup of that magnitude forming in the first place - when coupled with a user friendly non-caustic wheel cleaner they make it so easy and pleasant to maintain the drum. A small brush for around the nuts and you're set.
Iron-X or the like I'd recommend before your periodic wheel wax/sealant. So every six months for me. (but we don't have salted roads to deal with down under)
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2001 Boxster S, TipTronic in Seal Grey aka "The Imp"
2001 TE50, ESS in (now) Grigio Titanio Matallizzato aka "The Golden child"
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