Yes you can go less negative for less tire wear on the street. I have no idea how affects your handling as its dependent upon the cornering loads you get with your type of driving. You have to feel it or get some test data or go with someone's set-up
I am trying to figure out the same thing: how to get the optimum tire contact patch for the driving I do. For me this likely means more negative camber to deal with track. cornering loads...especially on the front tires
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